Cysteine catabolism and cysteine desulfhydrase (CdsH/STM0458) in Salmonella enterica serovar typhimurium.

نویسندگان

  • Tamiko Oguri
  • Barbara Schneider
  • Larry Reitzer
چکیده

Cysteine is potentially toxic and can affect diverse functions such as oxidative stress, antibiotic resistance, and swarming motility. The contribution of cysteine catabolism in modulating responses to cysteine has not been examined, in part because the genes have not been identified and mutants lacking these genes have not been isolated or characterized. We identified the gene for a previously described cysteine desulfhydrase, which we designated cdsH (formerly STM0458). We also identified a divergently transcribed gene that regulates cdsH expression, which we designated cutR (formerly ybaO, or STM0459). CdsH appears to be the major cysteine-degrading and sulfide-producing enzyme aerobically but not anaerobically. Mutants with deletions of cdsH and ybaO exhibited increased sensitivity to cysteine toxicity and altered swarming motility but unaltered cysteine-enhanced antibiotic resistance and survival in macrophages.

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منابع مشابه

Cysteine Catabolism and Cysteine Desulfhydrase ( CdsH / STM 0458 ) in 2 Salmonella enterica serovar Typhimurium

#To whom correspondence should be addressed: Larry Reitzer, Department of Molecular and 10 Cellular Biology, University of Texas at Dallas, RL11, 800 West Campbell Rd, Richardson, TX 11 75080 Phone: (972) 883-2502, Fax: (972) 8832409, Email: [email protected] 12 13 Cysteine is potentially toxic and can affect diverse functions such as oxidative stress, 14 antibiotic resistance, and swarming ...

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عنوان ژورنال:
  • Journal of bacteriology

دوره 194 16  شماره 

صفحات  -

تاریخ انتشار 2012